Importance Atopic dermatitis (AD) is a common chronic illness that has been associated with
variation in the filaggrin gene (FLG). Four variants are most often evaluated. Objectives To
comprehensively describe and compare results from targeted sequencing ofFLGloss-of-
function (LoF) variants in children of African and European ancestry and the association of
these variants with onset and persistence of AD. Design, Setting, and Participants This
prospective US cohort study assessed the genetic subcohort of the Pediatric Eczema …