The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort
BACKGROUND: Atopic dermatitis (AD) is a common skin disease that is characterized by
recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have
been associated with an increased risk of AD. OBJECTIVE: We sought to evaluate the effect
of individual FLG null mutations on the persistence of AD over time. METHODS: We
evaluated a multiyear prospective cohort study of children with AD with respect to FLG null
mutations (R501X, 2282del4, R2447X, and S3247X). We evaluated the association of these …
recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have
been associated with an increased risk of AD. OBJECTIVE: We sought to evaluate the effect
of individual FLG null mutations on the persistence of AD over time. METHODS: We
evaluated a multiyear prospective cohort study of children with AD with respect to FLG null
mutations (R501X, 2282del4, R2447X, and S3247X). We evaluated the association of these …
