[HTML][HTML] Regulation of effector and memory CD8 T cell differentiation by IL-2—a balancing act
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum
of physiological outcomes such as cell survival, proliferation, and effector differentiation. In
addition to driving effector differentiation, IL-2 signals are also critical for formation of long-
lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell
effector and memory differentiation by IL-2, wherein the timing, duration, dose, and source of …
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum
of physiological outcomes such as cell survival, proliferation, and effector differentiation. In
addition to driving effector differentiation, IL-2 signals are also critical for formation of long-
lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell
effector and memory differentiation by IL-2, wherein the timing, duration, dose, and source of …
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. In addition to driving effector differentiation, IL-2 signals are also critical for formation of long-lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell effector and memory differentiation by IL-2, wherein the timing, duration, dose, and source of IL-2 signals are considered in fine-tuning the balance of key transcriptional regulators of cell fate.
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