Promoter Choice Influences Alternative Splicing and Determines the Balance of Isoforms Expressed from the Mousebcl-X Gene
Differential splicing from the bcl-Xgene generates several isoforms with opposite effects on
the apoptotic response. To explore the mechanism controlling the balance between the
various isoforms, we have characterized the 5′ region of the mousebcl-X gene. We
identified three new promoters in addition to the two previously described (Grillot, DA, M., G.-
G., Ekhterae, D., Duan, L., Inohara, N., Ohta, S., Seldin, MF, and Núñez, G.(1997) J.
Immunol. 158, 4750–4757). These five promoters (P1-P5) would give rise to at least five …
the apoptotic response. To explore the mechanism controlling the balance between the
various isoforms, we have characterized the 5′ region of the mousebcl-X gene. We
identified three new promoters in addition to the two previously described (Grillot, DA, M., G.-
G., Ekhterae, D., Duan, L., Inohara, N., Ohta, S., Seldin, MF, and Núñez, G.(1997) J.
Immunol. 158, 4750–4757). These five promoters (P1-P5) would give rise to at least five …
