Dendritic cells (DC), while absent from the normal CNS parenchyma, have been
demonstrated in delayed type hypersensitivity (DTH), experimental allergic
encephalomyelitis (EAE), and some MS lesions. We demonstrate that an acute excitotoxic
lesion results in DC recruitment to the brain, with maximal cells between days 3 and 5.
Clodronate liposome-mediated depletion of cerebral perivascular macrophages does not
prevent recruitment of DC; however, a lesion in a whole-body irradiated animal does not …