Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of
vaccinated individuals is increasingly common with the circulation of highly immune evasive
and transmissible Omicron variants. Here, we report the dynamics and durability of recalled
spike-specific humoral immunity following Omicron BA. 1 or BA. 2 breakthrough infection,
with longitudinal sampling up to 8 months after infection. Both BA. 1 and BA. 2 infections
robustly boosted neutralization activity against the infecting strain while expanding breadth …
vaccinated individuals is increasingly common with the circulation of highly immune evasive
and transmissible Omicron variants. Here, we report the dynamics and durability of recalled
spike-specific humoral immunity following Omicron BA. 1 or BA. 2 breakthrough infection,
with longitudinal sampling up to 8 months after infection. Both BA. 1 and BA. 2 infections
robustly boosted neutralization activity against the infecting strain while expanding breadth …
Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection (preprint)
ABSTRACT SARS-CoV-2 breakthrough infection of vaccinated individuals is increasingly
common with the circulation of highly immune evasive and transmissible Omicron variants.
Here, we report the dynamics and durability of recalled spike-specific humoral immunity
following BA. 1 or BA. 2 breakthrough infection, with longitudinal sampling up to 8 months
post-infection. Both BA. 1 and BA. 2 infection robustly boosted neutralisation activity against
the infecting strain while expanding breadth against other Omicron strains. Cross-reactive …
common with the circulation of highly immune evasive and transmissible Omicron variants.
Here, we report the dynamics and durability of recalled spike-specific humoral immunity
following BA. 1 or BA. 2 breakthrough infection, with longitudinal sampling up to 8 months
post-infection. Both BA. 1 and BA. 2 infection robustly boosted neutralisation activity against
the infecting strain while expanding breadth against other Omicron strains. Cross-reactive …
