Immunohistochemical analysis of NOTCH1 and JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance
Notch signaling is implicated in the pathogenesis of multiple myeloma expressing high level
of active Notch proteins NOTCH1 and JAGGED1 in tumor plasma cells. We investigated
expression of NOTCH1 and JAGGED1 in bone marrow trephine biopsies of 80 newly
diagnosed multiple myeloma and 20 monoclonal gammopathy of undetermined significance
patients using immunohistochemical methods. The number of positive tumor cells was
counted per 1000 tumor cells and the intensity of staining was assessed semi quantitatively …
of active Notch proteins NOTCH1 and JAGGED1 in tumor plasma cells. We investigated
expression of NOTCH1 and JAGGED1 in bone marrow trephine biopsies of 80 newly
diagnosed multiple myeloma and 20 monoclonal gammopathy of undetermined significance
patients using immunohistochemical methods. The number of positive tumor cells was
counted per 1000 tumor cells and the intensity of staining was assessed semi quantitatively …
